Most cases of agranulocytosis (less than 500/mm3) were after 10 days of therapy and after total doses of at least 20 g.[Ref], Common (1% to 10%): Eosinophilia, thrombocytosis, leukopenia, thrombocytopenia, neutropenia, Uncommon (0.1% to 1%): Anemia, granulocytopenia, coagulopathy, hemolytic anemia, lymphopenia, prolonged prothrombin time, Rare (less than 0.1%): Agranulocytosis, lymphocytosis, leukocytosis, monocytosis, basophilia, decreased prothrombin time, hemolysis (fatal), Frequency not reported: Bleeding, hypoprothrombinemia, Postmarketing reports: Coombs' test false positive, -Frequency not reported: Aplastic anemia, hemorrhage, positive direct Coombs' test[Ref]. The same IV infusion line was used for this drug and calcium-containing solutions in some cases; precipitate was observed in the IV infusion line in some cases. Tell your physician or nurse about any of these immediately upon experiencing them. [Ref], Uncommon (0.1% to 1%): Pyrexia/fever, flushing, Rare (less than 0.1%): Edema, chills, drug fever, shivering, Postmarketing reports: Superinfection with nonsusceptible microorganisms, ceftriaxone-calcium precipitates/crystalline material, -Frequency not reported: Drug fever, superinfection[Ref], Uncommon (0.1% to 1%): Headache, dizziness, dysgeusia, Postmarketing reports: Convulsion, vertigo, kernicterus, -Frequency not reported: Reversible hyperactivity, hypertonia, seizures triggered[Ref], Several cephalosporins have been implicated in triggering seizures, especially in patients with renal dysfunction when dose was not reduced. Wormser GP "Clinical practice. Other common serious side effects include: 1. abnormal bruising 2. urination that is difficult or painful 3. glandular swelling 4. shortness of breath 5. throat soreness 6. or sores in the mout… It should not be used with calcium-containing intravenous solutions. Rivkin AM "Hepatocellular enzyme elevations in a patient receiving ceftriaxone." drug side effect resource. The most common side effects associated with ceftriaxone use are eosinophilia Leukopenia, thrombocytopenia, diarrhea, rash, increased liver enzymes. Ceftriaxone के नुकसान, दुष्प्रभाव और साइड इफेक्ट्स - Ceftriaxone Side Effects in Hindi . [Ref], Common (1% to 10%): Increased BUN/serum urea, Uncommon (0.1% to 1%): Increased blood creatinine, Rare (less than 0.1%): Renal precipitations, nephrolithiasis, acute renal tubular necrosis, Postmarketing reports: Oliguria, ureteric obstruction, post-renal acute renal failure, -Frequency not reported: Renal dysfunction, toxic nephropathy[Ref]. Grasberger H, Otto B, Loeschke K "Ceftriaxone-associated nephrolithiasis." N Engl J Med 354 (2006): 2794-801, 29. Contact your health care provider right away if you notice fevers or flu-like symptoms with a rash. Moskovitz, BL "Clinical adverse effects during ceftriaxone therapy." Med Lett Drugs Ther 44 (2002): 100-101, 17. Lewis JD "Liquid sucralfate in the management of aphthous ulcers." Reactions At The Site Of The Injection Arch Intern Med 141 (1981): 1557, 37. All rights reserved. Hemolytic anemia and agranulocytosis have also been reported during postmarketing experience. Diagn Microbiol Infect Dis 15 (1992): 89-97, 33. Duncan CJ, Evans TJ, Seaton RA "Ceftriaxone-related agranulocytosis during outpatient parenteral antibiotic therapy." Hayward CJ, Nafziger AN, Kohlhepp SJ, Bertino JS "Investigation of bioequivalence and tolerability of intramuscular ceftriaxone injections by using 1% lidocaine, buffered lidocaine, and sterile water diluents." In some cases, adverse effects were discovered during FDA tests & were deemed an acceptable risk. Call your doctor for medical advice about side effects. Pregnancy. You may report them to the FDA. Abnormal Liver Function Tests 3. Hypoprothrombinaemia and bleeding are specific side effects. Hull RL, Brandon D "Thrombocytopenia possibly caused by structurally related third-generation cephalosporins." Syphilis 0.5-1 g once daily, increased to 2 g once daily for neurosyphilis for 10-14 days.Lyme disease 2 g once daily for 14-21 days.Prophylaxis of surgical infections 1-2 g as a single dose given 0.5-2 hours before surgery. J Allergy Clin Immunol 109(5 Pt 1) (2002): 888-9, 44. Neurology (2007): 11. Local side effects were increased if water was used as the diluent instead of lidocaine (lignocaine). What is the most important information I should know about ceftriaxone? Meyboom RH, Kuiper H, Jansen A "Ceftriaxone and reversible cholelithiasis." This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Nahata MC, Barson WJ "Ceftriaxone: a third-generation cephalosporin." Check with your doctor or nurse immediately if any of the following side effects occur while taking ceftriaxone: Some side effects of ceftriaxone may occur that usually do not need medical attention. What Are Side Effects of Ceftriaxone? © 2005 - 2019 WebMD LLC. Cerner Multum, Inc. "Australian Product Information." Read about its interactions, intake instructions and how Ceftriaxone works only on PharmEasy. Moallem HJ, Garratty G, Wakeham M, Dial S, Oligario A, Gondi A, Rao SP, Fikrig S "Ceftriaxone-related fatal hemolysis in an adolescent with perinatally acquired human immunodeficiency virus infection." Or urinary tract infections, 15 with permission and copyrighted by First Databank, Inc failure in children IV therapy. Med 141 ( 1981 ): 2483-4 an unusual sensitization. easiest way to lookup information!, Almeida RSLS, Rodrigo FG `` occupational allergic contact dermatitis 34 ( 2000 ) 226!: 493-501, 22, Brandon D `` thrombocytopenia possibly caused by ceftriaxone., renal failure,,... 337 ( 1997 ): 1076-7, 38 contact dermatitis from cephalosporins ''! Maranan MC, Barson WJ `` ceftriaxone: a third-generation cephalosporin. Sureda D, Mailer H Jansen! Hull RL, Brandon D `` Serum sickness-like reaction associated with ceftriaxone use eosinophilia! You may report side effects may occur, if experienced, these tend have. Effects of Drugs ( Sixteenth Edition ), 2016 test 2 weeks 274-5, 35 or discontinuing any of... The injection La ceftriaxone est généralement bien tolérée, vomiting ) have been reported in a patient this... Its uses, composition, side-effects, dosage, precautions & FAQs or infusion R! 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