Risk Factors (cont’d) •Diabetes mellitus induces hypercholesterolemia. definition . Energy Metabolism Perfusion Shock Topics Define shock in terms of cellular function Review the requirements for adequate ... - Lack of sufficient oxygen (single most common cause of cellular injury) Causes ... Pernicious Anemia. - Predictors of Acute, Subacute and Late Stent Thrombosis After Acute MI Primary Angioplasty in the Horizons AMI Trial George D. Dangas, Alexandra J. Lansky, Early and late coronary stent thrombosis of sirolimus-eluting and paclitaxel-eluting stents in routine clinical practice: data from a large two-institutional cohort study. Pathogenesis of Antiphospholipid Antibodies in Pregnancy - . Thrombotic thrombocytopenic purpura (TTP) and hemolytic uremic syndrome (HUS) are acute thrombotic microangiopathies (TMAs) characterized by acute episodes of intravascular hemolysis, thrombocytopenia and microvascular thrombosis leading to end‐organ damage becoming apparent as acute kidney injury, cerebrovascular accidents or seizures, and myocardial … Well-defined familial predisposition such as hypertension and diabetes. Condition. Viral Pathogenesis - . USE PRECAUTION WITH GP IIB/IIIA INHIBITORS, HIGHER RISK OF SIDE EFFECTS WITH PTS 75 YEARS OF, 50 MG VIAL WITH ONE 10 ML VIAL OF STERILE WATER, MUST BE RECONSTITUTED, THEN USED IMMEDIATELY. “Response-to-Injury Hypothesis” for Development of Atherosclerosis 1. Contribution of bone marrow-derived cells Point of intervention Smoking Blood pressure Cholesterol Obesity Other factors Risk Thrombosis Heart attack Management and Prevention (cont’d). Arterial hypertension Ph. outline. To view this presentation, you'll need to allow Flash. Pathophysiology of thrombosis "Virchow’s Triad” is a term for three broad categories of risk factors that predispose to thrombosis. 72, 87-90 In addition, anticoagulation for arterial events and atrial fibrillation may be required. m.a.kubtan m.d-f.r.c.s. viral pathogenesis is the process by which a viral infection leads to disease. Thrombus may form on top of such a plaque. © 2020 SlideServe | Powered By DigitalOfficePro, - - - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - - -. The first step in COVID-19 pathogenesis is viral invasion via its target host cell receptors. At higher magnification, many foam cells (macrophages full of lipid material) and a cholesterol cleft are seen in this atheromatous plaque. •Smoking is a major risk factor and is thought to account for the recent increase in the incidence and severity of AS in women. It's FREE! Examples of Atherosclerosis of Human Arteries This is a normal coronary artery with no atherosclerosis and a widely patent lumen that can carry as much blood as the myocardium requires. Suggested Citation:"THE PATHOGENESIS OF THROMBOSIS. The three factors include: venous stasis, activation of blood coagulation, and vein damage. 2. Disseminated intravascular coagulation (DIC) - . HDL partakes in reverse transport of cholesterol presumably from atherosclerotic plaques. The dominant influence, and the one factor that by itself can lead to thrombosis, is endothelial injury.2,5,6 Endothelial Injury: Endothelial injury causes subendothelial collagen exposure and platelet adherence, among other changes; many factors can contribute to the injury, including hypertension, vasculitis, scarred valves, bacterial endotoxins, cholesterolemia, and chemicals … How- •Hypertension is a major risk factor for atherosclerosis and may well be more important than hypercholesterolemia after age 45. samar abu ouda 20060282. pathogenesis & immunopathogenesis. basic skeletal structures & functions. Prof. J. Plevkova MD, PhD. •Given alone for primary or secondary prevention of heart disease, these drugs can reduce the incidence of coronary artery disease by 25 – 60% and reduce the risk of death from any cause by ~30%. Bleeding and Thrombosis Disorders in the ICU - . **the signs and, Normal Bone Growth and the Pathogenesis of Osteoporosis - . 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