The most obvious cause of an elevated vitamin B12 level is taking too much of the vitamin in... Leukemia and Related Blood Diseases. Mine is high, 1637, but do take 2000 mcg daily. J Clin Endocrinol Metab. Alcoholic liver disease is an example of a liver condition associated with high vitamin B12. Taking certain medications, for instance, may affect the test results. Hematologic disorders like chronic myelogeneous leukemia, promyelocytic leukemia, polycythemia vera and also the hypereosinophilic syndrome can result in elevated levels of cobalamin. Older adults who have a vitamin B12 deficiency will likely have to take a daily B12 supplement or a multivitamin that contains B12. 2013;24(2):567-580. doi:10.1007/s00198-012-2224-2, Urashima M, Segawa T, Okazaki M, Kurihara M, Wada Y, Ida H. Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren. High vitamin B12 levels are associated with many blood diseases, including various types of leukemia and related blood disorders. Am J Prev Med. Arch Intern Med. Headache 3. I am not aware of any disease process that results in high levels of b12. Vitamin B-12 can cause very rare but serious allergic reactions (anaphylaxis). I thought this was really strange,” says Hope. Vitamin B12, which is commonly found in a variety of foods, including fish, meat, eggs, and dairy products, is essential for maintaining the health of the body's nerve and blood cells — it also helps make DNA. According to a September 2012 study in "PLoS One," people with high vitamin B12 had a 4- to 18-times higher risk of having a blood disease. Methods: Individuals with plasma B12 measurements were sampled from The Health Improvement Network primary care database, UK. Am J Clin Nutr. Health Effects of High Levels. Very high blood levels of vitamin B12 were tied to an increased risk of early death. This makes it nearly impossible to overdose on the nutrient. While vitamin B12 is generally not considered toxic in high levels, it's important to determine if the elevation is due to excess vitamin supplements since other causes of a high vitamin B12 level are usually serious. Urashima M, Segawa T, Okazaki M, Kurihara M, Wada Y, Ida H. Randomized Trial of Vitamin D Supplementation to Prevent Seasonal Influenza A in Schoolchildren. Holick MF. Hematologic disorders like chronic myelogeneous leukemia, promyelocytic leukemia, polycythemia vera and also the hypereosinophilic syndrome can result in elevated levels of cobalamin. Thank you. The most common diseases associated with high levels of the vitamin are kidney failure, blood cancers, leukemia, liver disease, polycythemia vera, and hypereosinophilic syndrome. The American Journal of Clinical Nutrition. Vitamin B12 is considered to be very safe. 2012;11:78. doi:10.1186/1475-2891-11-78, Carrillo AE, Flynn MG, Pinkston C, et al. J Clin Endocrinol Metab. Thank you. 2011;96(1):53-58. doi:10.1210/jc.2010-2704, Bouillon R, Van Schoor NM, Gielen E, et al. is a blood b12 level of 1400 too high? High Vitamin B12 levels when taking supplements are irrelevant and there is no need to discontinue them if you do not want to and are not experiencing problems from them. Chronic myeloid leukemia is one such disease, in which the elevated vitamin B12 levels are thought to be due to release of excess B12 carrier proteins from the cancerous white blood cells. University of Ottawa Evidence-based Practice Center. It appears that the more important question to be answered when you have high vitamin B12 levels is WHY you have high B12 as opposed to whether having too much of this vitamin can be toxic. what causes extremely high serum vit b12 levels? High levels of vitamin B12 in a person's blood are associated with an increased risk of early death, according to research published last month in the journal JAMA Network Open. 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